ChemicalBook > CAS DataBase List > 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
- Product Name
- 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
- CAS No.
- 86499-96-9
- Chemical Name
- 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one
- Synonyms
- 3-BroMo-2;IHT-PI BBC;3-Bromo-2,3,4,5-tetr;A-BROMOBENZOCAPROLACTAM;3-bromobenzocaprolactam;α-Bromobenzocaprolactam;ALPHA-BROMOBENZO-CAPROLACTAM;3-Bromo-2,3,4,5-tetrahydro-2H-;3-BromoTetrahydrobenazepin-2-One;5-Trtrahydro-2H-1-benzazepine-2-one
- CBNumber
- CB9777910
- Molecular Formula
- C10H10BrNO
- Formula Weight
- 240.1
- MOL File
- 86499-96-9.mol
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3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Property
- Melting point:
- 164 °C
- Boiling point:
- 383.2±42.0 °C(Predicted)
- Density
- 1.492±0.06 g/cm3(Predicted)
- Flash point:
- 185.542℃
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- slightly soluble in ethanol, benzene, acetone, insoluble in water
- pka
- 13.59±0.40(Predicted)
- CAS DataBase Reference
- 86499-96-9(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- B3393
- Product name
- 3-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $27
- Updated
- 2021/12/16
TCI Chemical
- Product number
- B3393
- Product name
- 3-Bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $81
- Updated
- 2021/12/16
TRC
- Product number
- B688283
- Product name
- 3-Bromo-1,3,4,5-tetrahydro-2h-1-benzazepin-2-one
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0021162
- Product name
- 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $618.5
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0021162
- Product name
- 3-BROMO-1,3,4,5-TETRAHYDRO-2H-1-BENZAZEPIN-2-ONE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $814.97
- Updated
- 2021/12/16
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3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Chemical Properties,Usage,Production
Uses
3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one is an intermediate in the synthesis of Benazepril Hydrochloride. Benazepril Hydrochloride is a first-line antihypertensive drug recommended by the WHO. It is a chiral drug with excellent clinical efficacy, strong safety and tiny side effects in the international antihypertensive drugs of angiotensin converting enzyme inhibitors.
Chemical Properties
White or almost white crystalline
Preparation
The preparation of 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one is as follows:10 parts by weight of the heated melted polyphosphoric acid was added to the drying kettle, With stirring, The above 2-bromo-3,4-dihydro-N-hydroxy- (2H) -naphthalimide was added in portions at a temperature of 60 ° C, Insulation reaction for 20 hours; The reaction solution was added dropwise to 12.5 parts by weight of water to carry out hydrolysis, Still Washed to give 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one crude; 10 parts by weight of methanol and 0.1 part by weight of activated carbon were added, Heating decolorization, After filtration, the filtrate was cooled to 10 ° C for 20 hours, centrifuged, washed and dried to give 3-bromo-1,3,4,5-tetrahydro-2H-1-benzazepan-2-one. The purity of the product was 3, 10-bromo-1,3,4,5-tetrahydro-2H-1-benzazepan-2-one as high as 99.6% and the yield was as high as 98%.
3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
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3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one Suppliers
- Tel
- 001-857-928-2050 or 1-888-588-9418
- Fax
- 001-617-206-9595
- sales@chemreagents.com
- Country
- United States
- ProdList
- 10194
- Advantage
- 62
- Tel
- (+1)-858-699-3322
- Fax
- (+1)-858-876-1948
- info@accelachem.com
- Country
- United States
- ProdList
- 19965
- Advantage
- 58
- Tel
- 8485655694
- sales@alchempharmtech.com
- Country
- United States
- ProdList
- 63711
- Advantage
- 58
- Tel
- +1-833-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
- 57511
- Advantage
- 58
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View Lastest Price from 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one manufacturers
Henan Fengda Chemical Co., Ltd
- Product
- 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 86499-96-9
- Price
- US $5.00-0.10/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-16
Hebei Yanxi Chemical Co., Ltd.
- Product
- 3-Bromo-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 86499-96-9
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10000
- Release date
- 2023-10-23
Changzhou Rokechem Technology Co., Ltd.
- Product
- 3-Bromo-2,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one 86499-96-9
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99%;USP/EP/CP
- Supply Ability
- 1-10000kgs
- Release date
- 2023-05-26
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